Structure-Based drug design (SBDD) has emerged as a popular approach in drug discovery, leveraging three-dimensional protein structures to generate drug ligands. However, existing generative models encounter several key challenges: (1) incorporating boundary condition constraints, (2) integrating hierarchical structural conditions, and (3) ensuring spatial modeling fidelity. To address these limitations, we propose SculptDrug, a spatial condition-aware generative model based on Bayesian flow networks (BFNs). First, SculptDrug follows a BFN-based framework and employs a progressive denoising strategy to ensure spatial modeling fidelity, iteratively refining atom positions while enhancing local interactions for precise spatial alignment. Second, we introduce a Boundary Awareness Block that incorporates protein surface constraints into the generative process to ensure that generated ligands are geometrically compatible with the target protein. Third, we design a Hierarchical Encoder that captures global structural context while preserving fine-grained molecular interactions, ensuring overall consistency and accurate ligand-protein conformations. We evaluate SculptDrug on the CrossDocked dataset, and experimental results demonstrate that SculptDrug outperforms state-of-the-art baselines, highlighting the effectiveness of spatial condition-aware modeling.

With the rapid expansion of scientific literature, scholars increasingly demand precise and high-quality paper recommendations. Among various recommendation methodologies, graph-based approaches have garnered attention by effectively exploiting the structural characteristics inherent in scholarly networks. However, these methods often overlook the asymmetric academic influence that is prevalent in scholarly networks when learning graph representations. To address this limitation, this study proposes the Mutual-Influence-Aware Recommendation (MIARec) model, which employs a gravity-based approach to measure the mutual academic influence between scholars and incorporates this influence into the feature aggregation process during message propagation in graph representation learning. Additionally, the model utilizes a multi-channel aggregation method to capture both individual embeddings of distinct single relational sub-networks and their interdependent embeddings, thereby enabling a more comprehensive understanding of the heterogeneous scholarly network. Extensive experiments conducted on real-world datasets demonstrate that the MIARec model outperforms baseline models across three primary evaluation metrics, indicating its effectiveness in scientific paper recommendation tasks.

Activity and behaviour correlate with dairy cow health and welfare, making continual and accurate monitoring crucial for disease identification and farm productivity. Manual observation and frequent assessments are laborious and inconsistent for activity monitoring. In this study, we developed a unique multi-camera, real-time tracking system for indoor-housed Holstein Friesian dairy cows. This technology uses cutting-edge computer vision techniques, including instance segmentation and tracking algorithms to monitor cow activity seamlessly and accurately. An integrated top-down barn panorama was created by geometrically aligning six camera feeds using homographic transformations. The detection phase used a refined YOLO11-m model trained on an overhead cow dataset, obtaining high accuracy (mAP\@0.50 = 0.97, F1 = 0.95). SAMURAI, an upgraded Segment Anything Model 2.1, generated pixel-precise cow masks for instance segmentation utilizing zero-shot learning and motion-aware memory. Even with occlusion and fluctuating posture, a motion-aware Linear Kalman filter and IoU-based data association reliably identified cows over time for object tracking. The proposed system significantly outperformed Deep SORT Realtime. Multi-Object Tracking Accuracy (MOTA) was 98.7% and 99.3% in two benchmark video sequences, with IDF1 scores above 99% and near-zero identity switches. This unified multi-camera system can track dairy cows in complex interior surroundings in real time, according to our data. The system reduces redundant detections across overlapping cameras, maintains continuity as cows move between viewpoints, with the aim of improving early sickness prediction through activity quantification and behavioural classification.

We posit that handwriting recognition benefits from complementary cues carried by the rasterized complex glyph and the pen's trajectory, yet most systems exploit only one modality. We introduce an end-to-end network that performs early fusion of offline images and online stroke data within a shared latent space. A patch encoder converts the grayscale crop into fixed-length visual tokens, while a lightweight transformer embeds the $(x, y, \text{pen})$ sequence. Learnable latent queries attend jointly to both token streams, yielding context-enhanced stroke embeddings that are pooled and decoded under a cross-entropy loss objective. Because integration occurs before any high-level classification, temporal cues reinforce each other during representation learning, producing stronger writer independence. Comprehensive experiments on IAMOn-DB and VNOn-DB demonstrate that our approach achieves state-of-the-art accuracy, exceeding previous bests by up to 1\%. Our study also shows adaptation of this pipeline with gesturification on the ISI-Air dataset. Our code can be found here.

Causality detection and mining are important tasks in information retrieval due to their enormous use in information extraction, and knowledge graph construction. To solve these tasks, in existing literature there exist several solutions -- both unsupervised and supervised. However, the unsupervised methods suffer from poor performance and they often require significant human intervention for causal rule selection, leading to poor generalization across different domains. On the other hand, supervised methods suffer from the lack of large training datasets. Recently, large language models (LLMs) with effective prompt engineering are found to be effective to overcome the issue of unavailability of large training dataset. Yet, in existing literature, there does not exist comprehensive works on causality detection and mining using LLM prompting. In this paper, we present several retrieval-augmented generation (RAG) based dynamic prompting schemes to enhance LLM performance in causality detection and extraction tasks. Extensive experiments over three datasets and five LLMs validate the superiority of our proposed RAG-based dynamic prompting over other static prompting schemes.

Background: The use of social robotics in elderly care is increasingly discussed as one way of meeting emerging care needs due to scarce resources. While many potential benefits are associated with robotic care technologies, there is a variety of ethical challenges. To support steps towards a responsible implementation and use, this review develops an overview on ethical aspects of the use of social robots in elderly care from a decision-makers' perspective. Methods: Electronic databases were queried using a comprehensive search strategy based on the key concepts of "ethical aspects", "social robotics" and "elderly care". Abstract and title screening was conducted by two authors independently. Full-text screening was conducted by one author following a joint consolidation phase. Data was extracted using MAXQDA24 by one author, based on a consolidated coding framework. Analysis was performed through modified qualitative content analysis. Results: A total of 1,518 publications were screened, and 248 publications were included. We have organized our analysis in a scheme of ethical hazards, ethical opportunities and unsettled questions, identifying at least 60 broad ethical aspects affecting three different stakeholder groups. While some ethical issues are well-known and broadly discussed our analysis shows a plethora of potentially relevant aspects, often only marginally recognized, that are worthy of consideration from a practical perspective. Discussion: The findings highlight the need for a contextual and detailed evaluation of implementation scenarios. To make use of the vast knowledge of the ethical discourse, we hypothesize that decision-makers need to understand the specific nature of this discourse to be able to engage in careful ethical deliberation.

Modern scene text recognition systems often depend on large end-to-end architectures that require extensive training and are prohibitively expensive for real-time scenarios. In such cases, the deployment of heavy models becomes impractical due to constraints on memory, computational resources, and latency. To address these challenges, we propose a novel, training-free plug-and-play framework that leverages the strengths of pre-trained text recognizers while minimizing redundant computations. Our approach uses context-based understanding and introduces an attention-based segmentation stage, which refines candidate text regions at the pixel level, improving downstream recognition. Instead of performing traditional text detection that follows a block-level comparison between feature map and source image and harnesses contextual information using pretrained captioners, allowing the framework to generate word predictions directly from scene context.Candidate texts are semantically and lexically evaluated to get a final score. Predictions that meet or exceed a pre-defined confidence threshold bypass the heavier process of end-to-end text STR profiling, ensuring faster inference and cutting down on unnecessary computations. Experiments on public benchmarks demonstrate that our paradigm achieves performance on par with state-of-the-art systems, yet requires substantially fewer resources.

Acute Coronary Syndromes (ACS), including ST-segment elevation myocardial infarctions (STEMI) and non-ST-segment elevation myocardial infarctions (NSTEMI), remain a leading cause of mortality worldwide. Traditional cardiovascular risk scores rely primarily on clinical data, often overlooking environmental influences like air pollution that significantly impact heart health. Moreover, integrating complex time-series environmental data with clinical records is challenging. We introduce TabulaTime, a multimodal deep learning framework that enhances ACS risk prediction by combining clinical risk factors with air pollution data. TabulaTime features three key innovations: First, it integrates time-series air pollution data with clinical tabular data to improve prediction accuracy. Second, its PatchRWKV module automatically extracts complex temporal patterns, overcoming limitations of traditional feature engineering while maintaining linear computational complexity. Third, attention mechanisms enhance interpretability by revealing interactions between clinical and environmental factors. Experimental results show that TabulaTime improves prediction accuracy by over 20% compared to conventional models such as CatBoost, Random Forest, and LightGBM, with air pollution data alone contributing over a 10% improvement. Feature importance analysis identifies critical predictors including previous angina, systolic blood pressure, PM10, and NO2. Overall, TabulaTime bridges clinical and environmental insights, supporting personalized prevention strategies and informing public health policies to mitigate ACS risk.

With the advent of large multimodal language models, science is now at a threshold of an AI-based technological transformation. Recently, a plethora of new AI models and tools has been proposed, promising to empower researchers and academics worldwide to conduct their research more effectively and efficiently. This includes all aspects of the research cycle, especially (1) searching for relevant literature; (2) generating research ideas and conducting experimentation; generating (3) text-based and (4) multimodal content (e.g., scientific figures and diagrams); and (5) AI-based automatic peer review. In this survey, we provide an in-depth overview over these exciting recent developments, which promise to fundamentally alter the scientific research process for good. Our survey covers the five aspects outlined above, indicating relevant datasets, methods and results (including evaluation) as well as limitations and scope for future research. Ethical concerns regarding shortcomings of these tools and potential for misuse (fake science, plagiarism, harms to research integrity) take a particularly prominent place in our discussion. We hope that our survey will not only become a reference guide for newcomers to the field but also a catalyst for new AI-based initiatives in the area of "AI4Science".

Verifying the provenance of content is crucial to the function of many organizations, e.g., educational institutions, social media platforms, firms, etc. This problem is becoming increasingly difficult as text generated by Large Language Models (LLMs) becomes almost indistinguishable from human-generated content. In addition, many institutions utilize in-house LLMs and want to ensure that external, non-sanctioned LLMs do not produce content within the institution. In this paper, we answer the following question: Given a piece of text, can we identify whether it was produced by LLM $A$ or $B$ (where $B$ can be a human)? We model LLM-generated text as a sequential stochastic process with complete dependence on history and design zero-shot statistical tests to distinguish between (i) the text generated by two different sets of LLMs $A$ (in-house) and $B$ (non-sanctioned) and also (ii) LLM-generated and human-generated texts. We prove that the type I and type II errors for our tests decrease exponentially in the text length. In designing our tests, we derive concentration inequalities on the difference between log-perplexity and the average entropy of the string under $A$. Specifically, for a given string, we demonstrate that if the string is generated by $A$, the log-perplexity of the string under $A$ converges to the average entropy of the string under $A$, except with an exponentially small probability in string length. We also show that if $B$ generates the text, except with an exponentially small probability in string length, the log-perplexity of the string under $A$ converges to the average cross-entropy of $B$ and $A$. Lastly, we present preliminary experimental results to support our theoretical results. By enabling guaranteed (with high probability) finding of the origin of harmful LLM-generated text with arbitrary size, we can help fight misinformation.